Objectives:
[a] To provide students with basic and applied organic chemistry in the area of pharmaceutical science and to prepare them to understand successfully other courses as biochemistry, medicinal chemistry, phytochemistry, pharmacokinetics and pharmacodynamics.
[b] To teach the students the theories, instrumentations, and selected applications of instrumental analysis
Contents:
Theoretical
It includes the chemistry of biologically active compounds as polynuclear hydrocarbons, halogen containing compounds, oxygen containing compounds, sulfur containing compounds, nitrogen containing compounds, heterocyclic compounds and stereochemistry of chiral molecules, stereoselectivity and stereospecificity of organic reactions, and the chemistry of steroids.
The course provides quantitative methods (precipitation titrations, gravimetry, complexometry, and oxidation-reduction reactions). In addition, it provides the basis of the following techniques: UV-Visible spectroscopy, infrared spectrometry, mass spectrometry, polarimetry, refractometry, fluorometry, phosphorometry, nuclear magnetic resonance, flame photometry, atomic absorption spectrophotometry, and electrochemistry, chromatography (TLC-paper, HPLC, GC, and capillary electrophoresis).
Practical
[a] Identification of binary mixture of two organic compounds. Synthesis and identification of some pharmaceutically active compound as aspirin and paracetamol.
[b] Quantitative and instrumental analysis of pharmaceutical compounds.
Principal Text:
*Organic Chemistry, RT., Morrison and RN Boyd, Sixth edition, Prentice Hall
Inc.2001
*Heterocyclic Chemistry, Ed., JA Joule and GF Smith, Third edition, Chapman & Hall
2000.
Principals of Instrumental Analysis, Douglas A. Skoog, F. James Holler, Timothy A.
Nieman, Saunders College Publishing, N.Y. (latest edition)
*HPLC Methods for Pharmaceutical Analysis, George Lunn, Norman R., Schmuff,
Wiley-Interscience (1997)
Supplementary Text:
Pharmaceutical Chemistry; Drug Synthesis, Ellis Harwood Limited.
Instrumental Analysis, Henry H. Bauer, Gary Christian and James E. O’Reilly, Allyn and Bacon Inc. London, (latest edition)
Practical High Performance Liquid Chromatography, Veronika Meyer, Wiley-Liss, NY (latest edition)