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Objectives:
Understanding fundamental concepts governing the relation between chemical structures of drugs and biological activity. Provide knowledge about the chemistry, biological activity and molecular mode of action of chemotherapeutic agents.
Contents:
Theoretical
Physical and chemical properties of drug in relation to biological activity including absorption, distribution, drug-receptor interaction, Hansch QSAR equation, drug bio-transformation. Chemical structures, biological activity and molecular mode of action of Chemotherapeutic agents including; antibiotics (semisynthetic and synthetic), disinfectants and antiseptics, sulfonamides, antimycobacterials, synthetic antimalarials, antifungals, antiamoebics, anthelmintics, antiviral agents and antineoplastic drugs.
Practical
Manipulation of pharmacopeias, limits tests, selected monographs. Computer aided conformational and cofigurational analysis of some pharmaceutical compounds.
Principal Text:
Textbook of Organic Medicinal and Pharmaceutical Chemistry. (Wilson and Gisvold's), J. N. Delgado, W. A. Remers. Lippincott – Revan Publishers.
Practical Pharmaceutical Chemistry. (5th Edition) Parts one and two. H. Beckett and J. B. Stenlake. The Athlone Press, London.
Supplementary Text:
Foye's Principals of Medicinal Chemistry. 5th Edition D. A. Williams and T. L. Lemke, Lippincott Williams and Wilkins
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